Zeitschrift für klinische und experimentelle Dermatologieforschung
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A Very Brief Overview of Hailey-Hailey Disease with Various Available Treatment Options

Bhavya Sri K

Hailey-Hailey disease is one of the rare genetic hereditary skin disease which is characterized by the presence of flaccid blisters and extensive rashes at various sites on skin like neck, groins, armpits, etc. It occurs equally in both males and females due to a point mutation in ATP2C1 gene which is indirectly responsible for cellular adhesion through SPCA1 (Secretory Pathway Calcium/manganese-ATPase) protein encoding. Proper diagnosis can differentiate Hailey-Hailey disease from other similar skin diseases. As the symptoms are remittent, there is no complete cure. However, life style modifications can help the patient by providing comfort. In this paper, we will briefly discuss about Hailey-Hailey disease along with various treatment options available.