Zeitschrift für Proteomik und Bioinformatik
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Analysis of Binding Properties of Phosphoinositide 3-kinase Through In silico Molecular Docking

P. Daisy, R. Sasikala and A. Ambika

Phosphoinositide 3-kinases (PI3-kinases) are increasingly considered to have a key role in intracellular signal transduction in health and disease. Particularly the enzymes plays vital role in wide range of cancer such as breast, ovarian, myeloid leukemia, prostate, Small Cell Lung cancer (SCLC) etc., Compounds such as Wortmannin, LYS2002 are the inhibitors of PI3-kinases but these compounds shown adverse side effects . Hence five natural flavanoids having inhibitory effects on PI3-kinase namely Andrographolide, Kaempferol, Luteolin, Quercetin and Gingerol were taken for in silico prediction of binding affinities of the protein PI3- kinase. Our reports can be used to develop new inhibitors with better binding affinities towards the protein PI3-kinase protein. For the binding analysis the catalytic subunit of the protein PI-3 Kinase p110? was taken for the study as it considered being a potential target in cancer treatment.