Zeitschrift für Proteomik und Bioinformatik
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Deciphering the Role of Long Non-coding RNAs in Cancer Using Modern Bioinformatics Approaches: A Comprehensive Review

Pankaj Jyoti Barua

The structural and molecular characterization of long non-coding DNA molecules has created tremendous scope for gaining insights into the molecular genetics of different types of malignancies. Studies have clearly indicated that these long-non coding DNAs are excellent candidates as far as cancer interventions are concerned and recent developments in different bioinformatics tools and paradigms have completely changed our cancer therapeutic and diagnostic outlook. The inherent objective of this review article in to present an overview on the molecular characteristics of lncRNAs and their role in cancer progression and discuss the far reaching implications for cancer diagnostics and therapeutics through bioinformatics analysis of lncRNAs. This review elaborates on the bioinformatics analysis of RNA-seq data from expression profiling of lncRNAs and also emphasizes on the significance of different lncRNA databases.