Haartherapie und Transplantation
Offener Zugang
ISSN: 2167-0951
ISSN: 2167-0951
Jaffe A, Nir Y, Zbar AP, Gonen-Shahar M, Gonen S
Objective: Alopecia areata is a common disorder 5-30% of cases representing alopecia totalis (AT) or alopecia universalis (AU), the most severe forms of the disorder. In the absence of any FDA-approved treatments, topical Hair UpTM has shown promising results but has not been subject to formal study. The following study reports the initial use of a customized natural topical treatment-Hair UpTM in an unselected population of AT and AU patients. It includes a cohort of patients with an intention to treat and aims to serve as a pilot study to a prospective study.
Methods: A retrospective analysis of AT/AU patients treated with topical Hair UpTM was conducted. The study assessed type of hair growth and the percentage hair regrowth using the severity alopecia tool (SALT) scoring system with a subjective determination of the cosmetic acceptability of response over a 2 year follow-up period.
Results: Of 109 subjects, 53 with available data were eligible for analysis including 26 minors <18 years of age (mean age 10.8+4.7 years) and 27 adults (mean age 39.1+12.2 years). There were 34 subjects with AU and 19 with AT. Treatment appeared to bevery safe with minimal contact reactivity. Almost all subjects achieved vellus hair growth (96%; 51/53) with 43% (23/53) developing full abundant hair and 81% (43/53) showing a return to quality vellus hair as early as 3 months after commencement of treatment. SALT scores exceeded 75% in 75% (21/28) of cases. Overall, 94% (17/18) of minors ultimately achieved a subjective cosmetically acceptable result compared with 58% (11/19) of adults (p=0.02).
Conclusion: Topical Hair UpTM treatment of subjects with Alopecia totalis (AT) and Alopecia universalis (AU) is effective and safe with a high rate of terminal hair regrowth and cosmetic acceptability, particularly in minors.