Zeitschrift für Nanomedizin und biotherapeutische Entdeckung
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Abstrakt

Pharmacokinetics of Maltodextrin Coated Cadmium Sulfide Quantum Dots in Rats

Lourdes Rodríguez-Fragoso, Ivonne Gutiérrez-Sancha, Jorge Reyes-Esparza and Patricia Rodríguez-Fragoso

Quantum Dots

(QDs) are rapidly becoming popular as novel tools for theragnostic purposes. This report evaluates the pharmacokinetics parameters of CdS-MDx QDs of different tissues following a single dose i.p. to rodents at several time points, as a model system for determining their tissue uptake, time of residence and elimination. We employed an analysis of tissue images using fluorescence microscopy and tissue homogenates by spectroscopy to identify and measure the CdS-MDx QDs content and analyze the concentration of QDs in each tissue at predetermined time intervals. The pharmacokinetics analysis of CdS-MDx QDs (Cmax, Tmax, AUC0-t, AUC0-∞, Ke and MRT) were different for each tissue after a single dose of QDs during 360 h. Liver and

kidney tissues

took up the most QDs, but their Ke and MRT evidenced a rapid kinetic of elimination, suggesting QDs might get eliminated by these organs. Our data clearly showed that CdS-MDx QDs were not completely cleared from in vivo systems after 360 h. CdS-MDx QDs appears to be nanomaterials with favorable pharmacokinetics properties to develop novel therapeutic and diagnostic modalities.