Zeitschrift für Proteomik und Bioinformatik
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Abstrakt

Proteomic Studies of the Effects of Different Stress Conditions on Central Carbon Metabolism in Microorganisms

Zoran Minic

The ability of cells to respond rapidly to fluctuations in environmental conditions such as thermal stress, pH, hypoxia, exposure to radiation, chemicals and a number of other factors is important for competitive fitness, adaptation and cell survival. To understand the dynamics of the complex metabolic pathways involved, various approaches including genomics, transcriptomics, proteomics, metabolomics, kinetics and biochemical information are appropriate. Proteomics is useful for evaluating the expression profiles of proteins, their post-translational modification and interactions between molecules. This review summarizes recent proteomics data examining the effects of different stress conditions on central carbon metabolism (CCM) in microorganisms. Data, primarily on enzymes involved in glycolysis, the tricarboxylic acid cycle and pentose phosphate pathways, were extracted from various sources, analyzed and are presented herein. Many proteomics analyses show that particular stress conditions affect the expression of specific enzymes of CCM or their pathways. Taken together, proteomic studies provide both an opportunity and a challenge for the study of the global regulation of CCM protein expression, posttranslation control of enzymes, and consequently the global regulation of enzymes under different stress conditions.