Anatomie und Physiologie: Aktuelle Forschung
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Abstrakt

A Brief Overview of Mechanobiology

Wasila Dadul

Through the integration of medicine, biology, engineering, and physics, Mechanobiology studies how the responses of cells, tissues, and organs to mechanical cues resulting from both intracellular generated and externally generated forces contribute to development, differentiation, physiology, and disease. Understanding how live cells detect their environment and respond appropriately in terms of shape, migration, proliferation, differentiation, and survival at numerous dimensions, from molecules to single cells, tissues, and organs, requires knowledge at multiple scales. Mechanical forces were postulated to drive embryogenesis and bone development more than a century ago. The role of mechanical forces for biological control was realized at the turn of the twentieth century in the study of developmental biology.