Zeitschrift für klinische und experimentelle Dermatologieforschung
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Abstrakt

Altered Expression of Epithelial Proteins in Hidradenitis Suppurativa

Sheila Criswell

Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition characterized by intradermal rupture of occluded pilosebaceous units which releases corneocytes and apocrine gland contents into the dermal compartment thereby eliciting a marked chronic inflammatory response. The direct cause of the severe and long-standing lesions in HS has not been elucidated. Using immunohistochemistry assays on formalin-fixed paraffin-embedded tissue sections, the current study assayed 27 of the more than 50 proteins directly responsible for corneocyte maturation and shedding in an attempt to describe alterations in protein expression which may be partially responsible for the firmly-cemented comedone plugs. Increased expression was found in A2ML1, CK 5/6, desmocollin 2/3, desmoglein 2, elafin, envoplakin, EphA2, filaggrin, involucrin, KLK6, KLK7, and plakophilin III, while decrease expression was seen in CK 1/10 and LEKTI. Together, these data suggest a multifactorial cause/effect which may explain the highly variable clinical course apparent in persons with HS.