Zeitschrift für Hepatologie und Magen-Darm-Erkrankungen
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An update on the Association of Gut-Liver Axis with Gut Micro biome Symbiosis Correlated NAFLD along with NAFLD- HCC with Potential Therapeutic Approaches: a Systematic Review

Kulvinder Kochar Kaur, Gautam Allahbadia, Mandeep Singh

Non-alcoholic Fatty Liver Disease (NAFLD) is believed to be amongst the maximum prevalent chronic liver disease globally secondary to pacey escalating obesity, Type 2 Diabetes Mellitus (T2DM), Metabolic Syndrome (MetS). In the form of a hepatic presentation of a metabolic disease NAFLD initiates with hepatic accrual along with propagationn towards hepatic inflammation; namely, Non-Alcoholic Steatohepatitis (NASH), hepatic fibrosis/ cirrhosis, with ultimate NAFLD associated Hepatocellular Carcinoma (NAFLD-HCC). Enhanced corroborate illustrated that gut microbiome possess an essential part in initiating besides propagatenag NAFLD via gut liver axis. The gut liver axis represents the reciprocal connection amongst gut as well as the liver constituted by the portal circulation, Bile Acids along with systemic circulation. This gut symbiosis aids in the generation of NAFLD by resulting in deregulation of gut - liver axis, causing escalated Intestinal permeability besides uncontrolled microbial metabolites transportation in the liver. Hence here we conducted a Thus here we conducted a systematic review utilizing search engine PubMed, Google scholar and others utilizing the MeSH terms like NAFLD; NASH; NAFLD–HCC; gut-liver axis; gut symbiosis Intestinal permeability; Bile Acids circulation ; portal circulation probiotics.; prebiotics; MT; individuals therapy treatment strategies, to update our earlier work from 2008 to 2022 till date. We found a total of 300 articles out of which we selected 103 articles for this update review. No meta-analysis was done. Thus we have described step by step the knowledge regarding gut micro biome symbiosis along with metabolomic alterations. Amongst steatosis NASH fibrosis along with NAFLD–HCC. Furthermore the different treatment strategies inclusive of probiotics. Prebiotics; FMT; individuals therapy treatment strategies, are detailed sides escalating Akkermansia muciniphilia amounts.