Zeitschrift für Nanomedizin und biotherapeutische Entdeckung
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Apoptotic and Anti-invasive Effects of Hybrid Liposomes without Drugs against Human Breast Cancer Cells In Vitro

Ichihara H, Motomura M and Matsumoto Y

Hybrid Liposomes (HL) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene (25) dodecyl ether (C12(EO)25) was examined to study the stimulation of apoptosis and antiinvasive actions against in vitro cultured human breast cancer (MCF-7) cells. The results obtained from the study reveals that HL suppressed the growth of MCF-7 cells without any drugs. Apoptosis for MCF-7 cells after subjecting them to HL treatment was noticed. To study the non-invasive actions of HL on the drifting of MCF-7 cells, we exercised Wound scratch assay. Non-invasive effects of HL on the migration of MCF-7 cells were obtained on the basis of wound scratch assay. HL suppressed the pseudopodium formation of MCF-7 cells. The study to determine the non-invasive effects of HL against MCF-7 cells were done by matrigel invasion assay which gave positive results due to inhibition of MT1MMP/MMP14 by HL.