Zeitschrift für klinische und experimentelle Dermatologieforschung
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Association between Vitamin D Deficiency and Psoriasis: A Case-Control Study

Ahmed Allayali, Ghassan Niaz, Khalid Al Hawsawi, Mohammad Fatani, Irfanullah Siddiqui, Razan Baghdadi, Hatim Al Sulimani and Waseem Al Hawsawi

The immunomodulatory effect of vitamin D is well known, and some previous studies have found a potential association between vitamin D deficiency and psoriasis. If this is the case, correction of vitamin D levels could provide a simple, cost-effective treatment method for psoriasis patients. The aim of this case-control study was to confirm whether there was such an association. We also investigated several potential risk factors of psoriasis. We recruited 68 consecutive psoriasis outpatients at three hospitals in Saudi Arabia, as well as 68 control patients with dermatological conditions, and compared serum 25-hydroxycalciferol levels. However, we found no significant differences in vitamin D levels between the two groups. This finding supports similar negative findings of some previous studies, but further studies are needed to resolve this matter.