Zeitschrift für klinische und zelluläre Immunologie
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Candidemia with Prosthetic Aortic Graft: Case Report

Dan Sun, Hongmei Jiao, Jiali Du, Ying Zhu, Zhifang Fu, Zeng Zeng, Bo Zheng and Alexa Lean

Infections of prosthetic aortic grafts status post-acute aortic dissection with Candida albicans (C. albicans) are rare. The gold standard of treatment for aortic graft infection is a combination of surgical resection and lifelong antimicrobial drug therapy, however postoperative mortality rates remain high. Here we present a 44-year-old man who presented with 2 months of fever, painful microembolic lesions localized to his right hypothenar eminence, right conjunctival hyperemia, right neural hearing loss, and a systolic murmur radiating from the aorta towards the neck. C. albicans was isolated from 3 separate blood cultures. Computed tomography (CT) displayed distinct thrombotic material affixed to the aortic prosthetic graft in the brachiocephalic artery. The patient was then treated with intravenous (IV) fluconazole for 8 weeks. During the treatment period, the patient suffered from brain hemorrhage in the right temporal lobe, presenting with hemiparalysis. After 8 weeks on IV fluconazole, oral fluconazole was then administered. Through 12 months of follow up, he remained asymptomatic, lab values only notable for slightly elevated inflammatory markers. This case suggests that for some patients, either unwilling or unable to endure surgery, candidemia associated with a prosthetic graft can be managed conservatively, with antifungal therapy alone.