Zeitschrift für Knochenforschung
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Chondrosarcoma Treatment: A Clinical Approach

Aakshi Kainthola

Chondrosarcomas are a diverse group of tumours that have one thing in common: the formation of cartilage matrix by tumour cells. After myeloma and osteosarcoma, chondrosarcoma is the third most frequent primary cancer of the bone. The majority of these tumours grow slowly and seldom spread, and after proper surgery, they have a good prognosis. They are thought to be relatively chemo- and radiation resistant due to their extracellular matrix, low percentage of proliferating cells, and limited vascularity. For intermediate- to high-grade cancers, wide surgical excision remains the best option. The clinical challenge for unresectable or metastatic disease is to prevent recurrence and discover better treatment alternatives. Treatment decisions should be decided by a team consisting of an experienced pathologist, radiologist, medical oncologist etc based on the radiological and histological classification in relation to clinical symptoms, medical history, and performance status.