Fortgeschrittene Techniken in Biologie und Medizin
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Abstrakt

Clinical Cases of Bacterial and Fungal Sensitization in Patients with Coxarthrosis and Gonarthrosis depending on Blood Group Differences

Dielievska V, Kravchun PG1, Leontieva 2, Marushchak 2, Ashukina NO, Danyshchuk ZN

Aim: To analyze bacterial and fungal sensitization in persons that have ability to absorb anti-A and anti-B antibodies incompatible with blood group type. Material and methods: 8 people had A blood group, 2 persons had B blood group, 22 persons showed O blood group type. 9 patients with O blood group and 2 patients with B blood group absorbed anti-A antibody. 2 patients with O blood group and 5 patients with A blood group absorbed anti-B antibody. 7 persons with 0 blood group without absorbing activity of anti-A, 4 persons with O blood group and 3 persons with A blood group without anti-B absorbing activity served as control groups. Leukocyte migration inhibition reaction was performed to estimate bacterial and fungal sensitization. Results: Persons with anti-A absorbing ability were characterized by increased antibodies, sensitization to Penicillium, Candida Albicans, Pseudomonas aeruginosa, E. Coli and Clebsiella pneumoniae, increased CIC as compared to those without anti-A absorbing ability. Patients with anti-B absorbing ability showed decreased spontaneous leukocyte migration inhibitory factor production, sensitization to Streptococcus pneumoniae and Staphylococcus aureus by cell type, sensitization to Candida Lusitaniae by humoral type. Persons with anti-A absorbing ability as compared to the persons with anti-B absorbing ability showed sensitization to Penicillium, Candida Albicans, while the persons with anti-B sensitization revealed sensitization to Streptococcus pyogenes. During incubation of erythrocytes with the heated polyclonal anti-A (and anti-B) and complement at room temperature the erythrocytes of the persons with corresponding anti-A (anti-B) absorbance were increased in size and agglutinated by sides. Conclusion: Anti-A and anti-B absorbing activity of erythrocytes is associated with different fungal and bacterial sensitization.