Zeitschrift für klinische und experimentelle Ophthalmologie
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Colour Vision Defect in Patients with High-Tension Glaucoma

Andrea Saifrtová, Jan Lešták, Jaroslav Tintěra, Zuzana Svatá, Lukáš Ettler, Pavel Rozsíval and Zuzana Veselá-Florová

Objective: To prove potential difference between black/white and yellow/blue stimulation when using functional magnetic resonance imaging (fMRI) examination in advanced stages of glaucoma disease.
Methods and materials: The authors examined eight patients with various stages of high-tension glaucoma using functional magnetic resonance imaging (fMRI). The group was compared to a group of eight healthy persons. Measurements were performed on the Philips Achieva 3T TX MR system using the BOLD method. Optical stimulation was provided by black/white and yellow/blue checkered patterns alternated with their negatives with a frequency of 2 Hz. Each measurement consisted of a sequence with five 30-second periods of active phase and five resting periods of the same length. The obtained data were processed by SPM8 software and GLM. The difference in the number of activated voxels when using the black/white or yellow/blue stimulations was tested by a t-test. Statistical maps of BW>YB and BW Results: The mean value of the difference in the number of activated voxels when using the BW vs. YB stimulation was 59% for the patients while for the controls it was only 2%. While the BW>YB difference between the control group and the patients differed by the statistically significant 1606 voxels (p=0.039), no difference was found for BW Conclusion:The authors showed that in the advanced stages of the glaucoma disease functional changes occurred in the cerebral cortex. The colour vision defect in the patients with high tension glaucoma was more significant than the authors had expected.