Zeitschrift für Nanomedizin und biotherapeutische Entdeckung
Offener Zugang

Abstrakt

Combined therapeutic medical device and stem cells for regenerative nanomedicine

N Benkirane-Jessel

In our group we explore a new generation of smart living implants combining not only active therapeutic but also stem cells, as a novel strategy to regenerate stabilized cartilage and avoid prosthesis by achieving regeneration of its sub-chondral bone foundation, requirement which is failing today in the clinic. In our group, a unique nanotechnology strategy is used to entrap, protect and stabilize therapeutic agents into polymer coatings: Nano-reservoirs, covering nano-fibers of implantable nanofibrous membranes for bone and cartilage regeneration. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nano-reservoirs. As cells grow, divide and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. The nanoreservoirs technology enables to reduce the quantities of required therapeutic agent (compared to soaked membranes for instance) thereby reducing costs. Feasibility and safety assessment of a therapeutic implant based on an active polymeric wound dressing and autologous mesenchymal stem cells derived from bone marrow for the treatment of femoral cartilage isolated lesions.