Zeitschrift für klinische und experimentelle Dermatologieforschung
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Effects of Nitric Oxide Activity on the Induction of Oxidative Stress in Skin Cell Signalling, Migration and Apoptosis

Mohammad Ali Nilforoushzadeh, Mohammadreza Razzaghi, Auob Rustamzadeh, Alimohammad Alimohammadi, Sona Zare, Susan Farshi

Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products. ROS can play, and in fact they do it, several physiological roles (i.e., cell signaling), and they are normally generated as byproducts of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) and xenobiotics (i.e., antiblastic drugs) contribute to greatly increase ROS production, therefore causing the imbalance that leads to cell and tissue damage (oxidative stress).