Zeitschrift für Leukämie
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Exploring the Role of Natural Killer Cell Receptors and HLA Ligands in Diffuse Large B-Cell Lymphoma Treatment: Potential Targets for Novel Therapies

Daniela Maira Cardozo*, Marangon Amanda Vansan, Guimarães Fernando, Visentainer Jeane, De Souza Cármino

Natural Killer (NK)1 cells play a crucial role in the response to treatment of patients with Diffuse Large B-Cell Lymphoma (DLBCL). The Killer-Cell Immunoglobulin-Like Receptors (KIR) expressed on the surface of NK cells and their respective Human Leukocyte Antigen (HLA) ligands expressed on the surface of target cells, command the main signaling pathways of NK cells. Understanding the binding profile of KIR receptors and their HLA ligands is of utmost importance in defining new strategies for therapies and treatment for DLBCL patients.