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FABRICATION AND DEVELOPMENT OF ONCE-DAILY LORNOXICAM BI-LAYER MATRIX TABLETS: FOR THE EFFECTIVE TREATMENT OF ARTHRITIS

Qamar Jamal Ahmad, Hariprasanna R.C, Upendra kulkarni, Basawaraj S.Patil, Rabbani G

The aim of this study was to prepare bi-layer tablet of Lornoxicam (LOR) for the effective treatment of arthiritis. LOR was formulated as immediate release layer and sustained release layer using hydrophilic matrix (hydroxypropylmethylcellulose [HPMC K15M]). The effect of concentration of hydrophilic matrix (HPMC K15M), binder (polyvinyl- pyrollidone [PVP K30]) and dissolution study of sustained release layer showed that an increasing amount of HPMC or PVP K30 results in reduced Lor release. The most successful formulation of the study, exhibited satisfactory drug release in the initial hours, and the total release pattern was very close to the theoretical release profile. All the formulations exhibited diffusion-dominated drug release.