Zeitschrift für pharmazeutische Pflege und Gesundheitssysteme
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Abstrakt

Formulation and Characterization of Hydrophilic Drug Tramadol Hydrochloride Nanoparticles in Transdermal Drug Delivery System

Mina Abbasnia, Reza Mahjub*, Alireza Vatanara

Objective: The aim of this study was to prepare gel containing Tramadol Hydrochloride Solid Lipid Nanoparticles (TRHC-SLNs) for Transdermal Drug Delivery System (TDDS).

Significance: Preparation of gel formulation containing solid lipid nanoparticles encapsulating Tramadol Hydrochloride was studied in order to use it as a topical analgesic agent in post-op and Cancer pain management without its addiction problems and short half-life.

Methods: The SLN formulations containing Tramadol Hydrochloride were prepared using glycerol monostearate (GMS) as the lipid matrix and soybean lecithin and tween 80 as the surfactant by Double Emulsification-Solvent Evaporation technique. The nanoparticles were optimized through a fractional factorial design. DPIs were prepared by lyophilization technique. The morphology of the particles was examined using transmission electron microscopy. The in vitro drug release profiles were evaluated.

Results: The particle size, PdI, zeta potential, entrapment efficiency and drug loading capacity of the optimized SLNs were 197 ± 57.25 nm, 0.21 ± 0.013, -19.8 ± 1.04 mV, 89.4 ± 2.38%, 9.49 ± 0.14% respectively. TEM images revealed de-agglomerated particles. In vitro release studies showed sustained release of Tramadol and the release kinetics were best fitted to the first order kinetic model.

Conclusion: The results found here indicated that TRHC-SLNs could be successfully prepared and stabilized through freeze drying.