Arzneimitteldesign: Offener Zugang
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Abstrakt

Global Current Trends in Drug Designing for Management of Type-2 Diabetes and Neurodegenerative Disorders

Haque A, Alam Q, Alam MZ and Kamal MA

Neurodegenerative diseases (NDs) and Type 2 diabetes (T2D) are progressive disorder often advances with age. T2D is characterized by hyperglycaemia, insulin resistance or relative lack of insulin uptake whereas NDs are characterized by the decline in cognitive function, diffuse deposition of amyloid plaques and neurofibrillary tangles in AD and degeneration of dopaminergic neurons in substantia nigra, leading to a reduction of striatal dopamine (DA) levels in PD. Since conventional drugs fail to surpass the natural CNS protective barriers, therefore, in order to overcome these hurdles, targeted drug delivery is of foremost significance for the treatment of AD and PD. New generation of drugs has discovered through innovative nanotechnology approaches such as polymeric nanoparticles are promising candidates in the investigation of AD because nanoparticles are capable of opening the tight junctions, crossing the BBB. Thus, there is a need to adopt current trend and newer strategies such as nanotechnological, computational and gene therapy approaches for drug design and delivery.