ISSN: 2471-9315
Ke Jia Dong, Wen Hua Li
Global cases and deaths showed that COVID-19 and 1918 influenza were not normal pandemics, but superpandemics. Was there a common mechanism to push pandemics into superpandemics? This common ground was explored here from a new perspective and approach using the Greatest Common Divisor (GCD). The results showed that superpandemic viruses played tricks like superbugs. One subtlety was that SARS-CoV-2 fighted antibodies, just as superbugs fighted antibiotics. The SARS-CoV-2 spike and ORF8 proteins recognized the “Achilles heel” of secretory antibodies, namely J-chains and secretory components, and hijacked them respectively. Another subtlety was that SARS-CoV-2 expanded ORF8 protein as a superpandemic catalyst, just as drug-resistant enzyme facilitated the spread of superbugs. The SARS-CoV-2 ORF8 protein corresponded to the 1918 H1N1 virus neuraminidase. Both functioned as glycosylated-modification enzyme and RNA base-modification enzyme. Tampering with the enzymes was not found in SARS-CoV and pandemic (H1N1) 2009 virus. The synergy of spike and ORF8 proteins acted as the ignition for SARS-CoV-2 superpandemic. Through GCD analysis of clinical and experimental results of different coronaviruses, it was proposed to comprehend the epidemiological traceability and evolutionary from virus sequence up to virus GCD. We sincerely recommend the GCD platform to WHO for early warning.