Fortgeschrittene Techniken in Biologie und Medizin
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Abstrakt

Impact of Fully Covered Metal Stent Placement in Refractory Postoperative Hilar and Anastomotic Strictures

Mitsuyoshi Honjo, Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Shujiro Tsuji, Nobuhito Ikeuchi, Kentaro Kamada, Reina Tanaka, Junko Umeda, Ryosuke Tonozuka, Shuntaro Mukai, Mitsuru Fujita, Fuminori Moriyasu and Hiroyuki Watanabe

Introduction: Biliary stricture can occur following surgeries of the biliary tract and can cause biliary congestion and cholangitis. Recently, fully covered self-expandable metal stent (FCSEMS) has been utilized for postoperative hilar and anastomotic strictures that have conventionally been considered difficult to treat. On the other hand, there is no solid evidence regarding optimal metal stent placement period.

Method: Retrospective review of patients treated for postoperative benign biliary stricture using a FCSEMS at our hospital between 2013 and 2015.

Results: We performed a total of 14 metal stent placements for 12 patients with postoperative benign biliary stricture. In all the patients, the metal stents were placed endoscopically and removed safely after the placement. The mean duration of stent placement was 47.9 days (28-144), and there was no retrograde cholangitis observed during metal stent placement. Following metal stent removal, the stricture improved in 9 patients. Recurrence developed in 3 patients, recurring bile duct stones in 2 patients, and cholangitis in 1 patient. Adverse events included post-ERCP pancreatitis in 2 patients, which was alleviated by stent removal the following day and conservative treatment in 1 patient, and conservative treatment only in the other patient. Distal stent migration was observed in 2 patients.

Conclusion: The present results suggest that stricture improvement can be expected in a shorter period by metal stent placement in patients with refractory postoperative biliary stricture. In patients with bile duct stones, lithectomy can be safely and effectively performed following metal stent expansion; however, further studies are required.