Zeitschrift für Hämatologie und thromboembolische Erkrankungen
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Interesting Collision between an Indolent B-Cell Lymphoma and a Microsatellite Unstable Adenocarcinoma of the Colon

Rebecca A Redman and Jason Chesney

Neoplastic transformation of lymphocytes involves a multitude of genetic alterations that result in clonal expansion. Cognate activation of lymphocytes against foreign and self antigens similarly results in clonal expansion and there have been prior reports of simultaneous clinical presentations of lymphomas and autoimmune disorders. In this case report, we report a rare collision of an indolent B cell lymphoma with a MLH1- negative microsatellite unstable colon cancer. We present a hypothesis whereby repeated immune stimulation by tumor neopeptide antigens predisposes otherwise normal B cells to neoplastic transformation. We believe that this case provides hypothesis-generating clinical data for improving our understanding of the interplay between B cell activation and their potential to transform into lymphoma cells.