Zeitschrift für klinische und zelluläre Immunologie
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Lack of Correlation between CCL5 -28C/G Functional Polymorphism and Multiple Sclerosis in Tunisian Patients

Nadia Ben-Fredj, Walid Ben-Selma, Saber Chebel, Mahbouba Frih-Ayed, Mahmoud Letaief, Aouni Mahjoub and Jalel Boukadida

Multiple sclerosis is a chronic demyelinating disease of the human central nervous system (CNS) of a still unknown etiology. CCL5 is localized in white matter tracts undergoing demyelination, suggesting that this chemokine participates in the pathogenesis of disease by attracting inflammatory cells into the CNS. The CCL5 -28C/G functional polymorphism have been reported to be associated with multiple sclerosis, however, evidence remains conflicting. In the current study, we investigated distibution of the CCL5-28C/G in 51 patients with multiple sclerosis in comparison to 162 healthy blood donors. The data revealed no significant differences in the distribution of the CCL5-28C/G polymorphism in multiple sclerosis patients compared with the control group. To conclude, our study showed no association between CCL5 -28C/G polymorphism and risk development of multiple sclerosis in Tunisian patients.