Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
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Lifestyle Risk Factors Associated with Threatened Miscarriage: A Case-Control Study

Tan TC, Neo GH, Malhotra R, Allen JC, Lie D and Østbye T

Background: Threatened miscarriage occurs in 20% of pregnancies. We conducted a case-control study to assess the association between maternal lifestyle factors and risk of threatened miscarriage.
Methods: Cases were 154 women presenting with threatened miscarriage in the 5th to 10th weeks of
gestation; controls were 264 women without threatened miscarriage seen in antenatal clinic in the 5th to 10th week of pregnancy. Lifestyle variables were: current and past cigarette smoking, current second-hand cigarette smoke exposure, computer and mobile-phone use, perceived stress, past contraceptive use, past menstrual regularity and consumption of fish oils, caffeine and alcohol. Logistic regression was performed.
Results: In multivariate analysis, we found a positive association of threatened miscarriage with second-hand smoke exposure (OR 2.93, 95% CI 1.32–6.48), computer usage (>4 hours/day) (OR 6.03, 95% CI 2.82– 12.88), mobile-phone usage (>1 hour/day) (OR 2.94 95% CI 1.32–6.53) and caffeine consumption (OR 2.95 95% CI 1.57–5.57). Any fish oil consumption was associated with reduced risk of threatened miscarriage (OR 0.20, 95% CI 0.09–0.42).
Conclusions: Prolonged mobile phone and computer use and fish oil supplementation are potential novel correlates of threatened miscarriage that deserve further study.