Internationale Zeitschrift für Physikalische Medizin und Rehabilitation
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Micro Active Plus Curcumin Reduces Pain in Patients with Osteoarthritis

Christopher Topar, Luke Stancs, Janice Havansy, Sarika Shah, Lior Cohen, Anushka Bhat, Jaskomal Phagoora, Kaitlin Carroll*

Background: Naturally occurring anti-inflammatories, such as curcumin, have the potential to decrease pain in patients with symptomatic Osteo Arthritis (OA) and allow them to increase their physical activity without serious side effects. Despite the low bioavailability of pure curcumin, it has been shown to reduce pro-inflammatory molecules. Research has shown that Micro Active plus Curcumin has 9.7x more bioavailability than 95% pure curcumin powder.

Purpose: This current study aimed to compare the standard dose of naproxen (220 mg twice daily) to Micro Active plus Curcumin (500 mg twice daily) in the pain reduction in patients, diagnosed with symptomatic OA.

Results: There were 100 patients included in this study that were randomized into one of two groups, for a total of 50 patients per group. There were no difference in demographics between groups (p=0.741) or difference in distribution of OA grade between groups (p=0.34). Patients in the Micro Active Plus Curcumin group reports a decrease in pain after an average of 2.3 weeks. There was no difference in pain control between groups (p=0.514). In patients who took NSAIDs daily, 12% patients did not tolerate the treatment due to GI issues compared to 8% in Micro Active plus Curcumin group.

Discussion and Conclusion: In our study, Micro Active plus Curcumin was tolerated better than naproxen and shown to reduce pain in all patients. The use of Micro Active plus Curcumin should be considered as primary intervention for patients with OA pain.