Fortgeschrittene Techniken in Biologie und Medizin
Offener Zugang
ISSN: 2379-1764
ISSN: 2379-1764
Utpal Bhadra*, Pradipta Patra and Manika Pal-Bhadra
Neuron driven physiological activities such as sleep, feeding, energy consumption are controlled by light sensitive central clock genes in the pacemaker neurons in the brain. Multiple epigenetic events including post-transcriptional regulation, splicing, polyadenylation, mature mRNA editing and stability of translation products are the main vibrators for circadian oscillation with the instructive role of various sets of non-coding small regulatory RNA. Here, we sum up the basic role of small regulatory RNA and their epigenetic circuits in brain clock activity.