Zeitschrift für Knochenforschung
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Osteogenesis Imperfecta

Aakshi Kainthola

Osteogenesis imperfecta (OI) is a category of bone-related hereditary diseases. The word "osteogenesis imperfecta" refers to a defect in the creation of bones. Bones in people with this illness are prone to breaking (fracture), often as a result of minor trauma or for no apparent reason. Multiple fractures are common and can occur even before birth in extreme circumstances. Milder cases may only result in a few fractures throughout the course of a person's life.There are 19 different types of osteogenesis imperfecta, ranging from type I to type XIX. Although their indications and symptoms overlap, there are several varieties that can be recognised by their signs and symptoms. Rarer varieties of osteogenesis imperfecta are defined by genetic factors. The mildest form of osteogenesis imperfecta is Type I (also known as classic non-deforming osteogenesis imperfecta with blue sclerae). The most severe form is Type II (also known as perinatally fatal osteogenesis imperfecta).Types III (progressively deforming osteogenesis imperfecta) and IV (common variable osteogenesis imperfecta with normal sclerae) of this disorder feature indications and symptoms that are in the middle of these two extremes