Anatomie und Physiologie: Aktuelle Forschung
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Abstrakt

protection of hydrogen sulfide in hyperhomocysteinemia

Utpal Sen

Homocysteine (Hcy) is a sulfur-containing amino corrosive, which structures as a halfway during methionine digestion. Elevated levels of plasma Hcy, otherwise called hyperhomocysteinemia (HHcy), are consistently related with kidney inadequacy [4,5,26,31]. Results from later contemplates have shown that HHcy downregulates hydrogen sulfide (H2S) level  and decreases endothelial nitric oxide synthase (eNOS) . What's more, through irregularity of lattice metalloproteinases (MMP) also, tissue inhibitor of metalloproteinases (TIMP), Hcy aggregates extracellular network (ECM) protein in the peri-glomerular space . These add to renovascular renovating including renal fibrosis and brokenness. In spite of the fact that Hcy is known for free vascular hazard factor, the system of renal fibrosis in HHcy is generally obscure. In the tissue, Hcy anyway processes by three endogenous.