Zeitschrift für Zellwissenschaft und Therapie
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Abstrakt

Ras Signaling Pathway, Historical View

Fahad G B Alanazi, Badi Q Alenazi, Abdulaziz D Al- Faim, Omar Bagadir, Ali Al- Shangiti, Omar Kujan, Bassel Tarakji, Saeed M Daboor, Mohamed W Al- Rabea, Waleed Tamimi, Dhaifallah Alenizi, Entissar AlSuhaibani and Faris Q Alenzi

It is increasingly clear that the three RAS genes, N-. H- and K-RAS, encode 21 kDa proteins which act as intracellular switches, play a signal transduction pathway in controlling cell growth and differentiation. The three genes are highly homologous, yet recent evidence suggests they may have distinct functions in different cell types and have a central role in many human diseases. This article reviews briefly the regulation of signaling mechanisms.