Zeitschrift für klinische und experimentelle Dermatologieforschung
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Sebaceous Cell Carcinoma: A Persistent Challenge in Clinical and Histopathological Diagnosis

Denise Miyamoto, Beatrice Wang, Cristina Miyamoto, Valeria Aoki, Li Anne Lim, Paula Blanco and Miguel N Burnier

Sebaceous cell carcinoma continues to defy clinicians and pathologists in terms of early diagnosis. The tumor may be mistaken as benign lesions such as chalazion and blepharitis, and also as malignant neoplasms, mainly basal cell carcinoma and squamous cell carcinoma. Despite advances in immunohistochemical analysis and treatment options during the last decades, morbidity and metastasis rates remain high. Prognosis is strongly related to the length of time between diagnosis and initiation of treatment, which reinforces the importance of early recognition of this condition. This article reviews key features of sebaceous cell carcinoma, from epidemiology to treatment, and new strategies to improve outcome.