Arzneimitteldesign: Offener Zugang
Offener Zugang

Abstrakt

Sensitive Quantitative Predictions of mhc Binding Peptides and Fragment Based Peptide Vaccines From Trichinella spiralis

Gomase VS and Chitlange NR

Trichinella spiralis is a nematode parasite, occurring in rats, pigs, bears and humans, and is responsible for the disease trichinosis. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Trichinella spiralis are important determinant for protection of host form parasitic infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 439 amino acids, which shows 432 nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Trichinella spiralis.