Zeitschrift für klinische Toxikologie
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Severe Amlodipine and Valsartan Overdose: A Case Report Describing the Utilization of Thermodilution and Pulse Contour-Based Hemodynamic Assessment

Shimon Firman, Baruch M Batzofin, Peter V van Heerden, Akiva Nachshon

Intentional overdose with either Calcium Channel Blockers or Angiotensin Receptor Blocker individually typically does not cause severe hemodynamic instability. However, a combined overdose with agents of both classes is known to increase the risk for hemodynamic instability, and may worsen the clinical course. We describe such an overdose, with detailed hemodynamic monitoring using thermodilution and pulse contour analysis tracking the clinical course. In addition, we wish to emphasize the scarce evidence supporting treatment strategies for overdose with this combination of drugs and the need for a patient-based decision-making process in such cases.