Gynäkologie und Geburtshilfe
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Sichelzellenanämie: Prognose für Mutter und Neugeborenes während der Gravido-Puerperalität am Universitätsklinikum Borgou

Sèdjro Raoul Atade, Sidi Imorou Rachidi, Bassowa Alika, Gogan Dorine Merveille, Togenon Lionel, David, Bouraima Kassirath, Aifa Florence, Sale Leilath, Jossou Christiane, Salifou Kabibou

Introduction: Pregnant women with sickle cell disease have a high risk of morbidity and mortality. Objective : This study sought to investigate the maternal and neonatal prognosis of sickle cell disease from 2017 to 2021 at the Departmental University teaching Hospital of Borgou (CHUD/B). Method: This was a retrospective cross-sectional study with descriptive and analytical purposes, carried out in the mother-child department and intensive care unit of the Departmental University teaching Hospital of Borgou (CHUD/B). Data collection was carried out from February 5, 2022 to June 5, 2022. A non-probability sampling technique with exhaustive recruitment of participants meeting the inclusion criteria was used. Pearson's Khi2 or Fisher's exact tests were used accordingly. Result: A total of 128 medical records of sickle cell pregnant women were reviewed with 97 (75.8%) SC type and 31 (24.2%) SS type. The hospital frequency of sickle cell disease was 0.99%. The most frequent childbirth route in these women was caesarean section (90.6%) of which 72.16% was prophylactic with the sole indication of sickle cell disease. The main complications found following childbirth were severe anemia (66.7%), vaso-occlusive crisis (29.6%), and puerperal infection (25.8%). Maternal mortality related to sickle cell disease was 11.72% while neonatal mortality was 8.1%. In addition, SS sickle cell patients were more likely to be anemic (p=0.0320), to be transfused (p=0.0086) and to give birth to a baby deceased in utero (p=0.016) than SC sickle cell patients. The fetal prognosis is twice as bad in SS sickle cell women than in SC women (p=0.049). Conclusion: Pregnancy on sickle cell disease is associated with multiple prenatal and postnatal complications at the CHUD-B. SS women are more likely to have more complications than SC women.