Alizadeh S, Beige ZB, Poor Heravi SA, Nejad FS, Shokri MM and Nazar M
Thrombospondins (TSP) are a group of multifunctional secretion proteins that consist of TSP-1 to TSP-5. TSP-1 is the first protein member of this family and a homotrimeric glycoprotein with a multifunctional domain. The aim of this study is to evaluate the level of TSP-1 and its impact on vessels in diabetic patients.
In 2016, 90 diabetic patients were selected from Golestan hospital and Emam Khomeini hospital, they were put into three different groups; 30 patients (FBS over 126 mg/dL) without a diabetic foot ulcer (DFU) (group 1), 30 diabetic patients (FBS over 126 mg/dL) with a DFU (group 2), 30 people without diabetes or DFU (group 3). In all patients, Hemoglobin A1c (HbA1c), blood sugar, and TSP-1 tests were performed.
Results: The mean amount of TSP-1 in group 1, 2, and 3 was 266.85 ± 88.75 ng/mL, 234.87 ± 129.8 ng/mL, and 1570.42 ± 1047.42 ng/mL, respectively. The average level of HbA1c in group 1 was 8%, in group 2 it was 10%, and in the normal group it was 5%. The results of the statistical tests indicated that there is a significant difference in TSP-1 level between the diabetic group without DFU and the diabetic group with DFU (p value=0.01).
Conclusion: Lack of TSP-1 expression is accompanied by VEGF high expression and reduction of TGF-Æ. Lack of TGF-Æ can cause immunological diseases, inflammation, growth diseases, wound healing reduction, and an increase in occurrence of tumors. High expression of VEGF leads to excessive proliferation of vessel endothelial cells. The result of the study indicated that TSP-1 has a significant role in inhibition of angiogenesis. As blood sugar and HbA1c levels increase, TSP-1 levels decrease, which causes foot ulcers due to vessel complications? However, these complications can be avoided by controlling diabetes.