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Abstrakt

Tamarind Seeds Polysaccharide (TSP) as sustained release polymer in Diclofenac Sodium Tablets

Tagwa M. Alfatih1*, Amira B. Abdelgader1*, Fatima S. Mohamed1*, Alaa S. Haider1*, Enas Salah1*, Omnia A. Elbashir1*, Mohammed A. Elhassan2, Sarra B. Shakartalla2, Abdelgadir A. Abdelgadir3,4, Elhadi M. Ahmed3

Controlled release drug delivery systems are gaining importance in the recent years for their clinical benefits which are not obtained from conventional oral drug delivery. Natural polysaccharides are the choice of materials among the hydrophilic polymers used, because they are nontoxic, less expensive, and widely available. One such polysaccharide is Tamarind Seeds Polysaccharides (TSP) which isolated from the tamarind kernel powder. This study is aimed to formulate tablet of diclofenac sodium with tamarind seeds polysaccharides by wet granulation technique, evaluate drug release characteristics, and compare it with the release profile of conventional tablets and that formulated with synthetic polymer Hydroxy Propyl Methyl Cellulose (HPMC). The results of the study was indicated that the drug release was extended over a period of 8 hours with tablets formulated with TSP and HPMC with a percentages 78.63%, 74.68% respectively. This study was put attention towards natural excipients which attribute to their safety, freely available, and cheap compared to synthetic one. TSP tablets stability and in vivo drug release should be further studied.