Anästhesie und klinische Forschung
Offener Zugang
ISSN: 2155-6148
ISSN: 2155-6148
Selda Sen, Turhan Dost, Osman N. Aydin, Mukadder Serter and Sadun Temocin
Background and objectives: The aim of the study is to evaluate the effect of combination of nitroglycerin and lornoxicam on nociception and antioxidative system in rats. Methods: Thirty-nine Wistar male rats were divided into five groups; control group (Group C, n=7), isotonic group (0.09 sodium chloride, Group ISO, n=8 ), lornoxicam group (lornoxicam 1.3 mg kg-1, Group L, n=8), nitroglycerin group (nitroglycerin 1 mg kg-1, Group N, n=8), and lornoxicam-nitroglycerin combination group (1.3 mg kg-1 lornoxicam+1 mg kg-1 nitroglycerin Group L+N, n=8). Hot plate test was applied in all groups before and at 30, 60, 90 minutes after drug injections by intraperitoneal route. Malondialdehyde, nitric oxide, glutathione, and catalase concentrations were measured before and after 90 minutes of drug injection in all blood samples. Results: The latency response of hot plate test was increased in Group L+N at 30 minutes, and Group L and Group L+N at 60 and 90 minutes (p<0.05). Malondialdehyde levels were decreased, while catalase and glutathion levels were increased in N and L+N groups (p<0.05). Conclusion: Nitroglycerin enhances the antioxidative effects of lornoxicam for antinociception but different mechanisms might also play a role on antinociception. Further studies must be carried out with experimental models and different drug doses to reach an ultimate conclusion.