Chemotherapie: Offener Zugang
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Abstrakt

The Association between the C1772T Genetic Polymorphism in Human HIF-1α Gene and Breast Cancer Risk: A Meta-analysis

Cheng K, Yuan Shen Y, Liu J, Wang XH, Hua YI, Jia ZM, Han Y, Sun HG and Yang ZL

Purpose: This meta-analysis aims to investigate the association between the C1772T genetic polymorphism in human HIF-1α gene and breast cancer risk.
Methods: PubMed and Embase databases were searched till October 2013 to identify eligible studies. A total of 2143 cases and 2046 controls from 6 studies were included in this paper. Allelic and genotypic comparisons between cases and controls were evaluated. Subgroup analyses by ethnicity were also performed.
Results: The recessive model, dominant model, comparison suggested that the genotype C1772T polymorphism was not significant without the increased breast risk: OR=1.38 [95% CI (0.35, 5.46)], P=0.65 and OR=1.14 [95% CI (0.83, 1.55)], P=0.43, respectively. The results for the co-dominant model comparison were not different with the results as follows: OR=1.10 [95% CI (0.83, 1.46)], P=0.50 and OR=1.41 [95% CI (0.34, 5.75)], P=0.64, respectively. The data of the allele results with OR=1.09 [95% CI (0.80, 1.48)], P=0.59, were not significant. Subgroup analyses by ethnicity were performed in the co-dominant model(TT versus CC)，recessive model, and the allele model with the increased breast cancer risk in the Asia: OR=4.42 [95% CI (1.60, 12.21)], P=0.004, and OR=4.16 [95% CI (1.51, 11.48)], P=0.006, and OR=1.28 [95% CI (1.05, 1.55)], P=0.01, respectively.
Conclusions: This meta-analysis suggests that the C1772T polymorphism is significantly associated with breast cancer risk in Asia. However, we find that the C1772T polymorphism is not associated with breast cancer risk on the whole.