Zeitschrift für klinische und zelluläre Immunologie
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The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment

Wael M Gabr, Mohamed Saad1, Maha Bilal

Background: Cognitive Impairment (CI) is a common manifestation of Multiple Sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medical management of MS patients.

Objectives: To correlate MS related CI to cortical brain lesions using brain for Magnetic Resonance to Imaging (MRI).

Materials and methods: Cognitive of impairment was detected using to that Mini Mental State Examination (MMSE), Neurological examination and brain MRI were performed for all patients. Correlation were calculated between disease cortical burden detected by MRI and CI.

Results: Fifty-three patients with proven MS were scanned by brain MRI, 69.8% of them had cognitive impairment diagnosed with mmSE. The presence and severity of cognitive impairment was correlated to cortical brain lesion. Cognitive impairment was not correlated with non-cortical brain lesions or neurological physical disability measured by Expanded Disability Status Scale (EDSS).

Conclusions: Presence of brain frontal cortical lesions detected by MRI in MS patients can predilect subsequent development of MS-related CI.