Zeitschrift für Hämatologie und thromboembolische Erkrankungen
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Abstrakt

Therapeutic Red Cell Exchange (RCE) and Its Clinical Utilisation

Mobin Paul, Priyanka CG, Latha K Abraham, Sophy MP, Dasary Varghese

There are many case reports and studies available in the medical literature that emphasise the importance of erythrocytapheresis usage in treatment of severe sickle cell anaemia and severe malarial infection. In the present study therapeutic red cell exchange was performed in two cases of homozygous sickle cell disease and one case of severe malarial infection. In case one and two the red cell exchange was performed to prevent the perioperative complications in sickle cell disease. In the third case the procedure was performed as an adjunct therapy to reduce the parasitic index of severe malarial infection. The study concludes that with one cycle of RCE patient’s pathological RBCs such as HbS in sickle cell disease has come down drastically and the patient underwent successful hip transplantation procedure without complications. In the case of malarial infection therapeutic red cell exchange was helpful in rapid reduction of the parasitic load. However, the patient couldn’t survive due to multiorgan failure.