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Use of Photodynamic Therapy for a Rare Inflammatory Skin Disease: Extragenital Lichen Sclerosus

Nello Tommasino, Luigi Coronella, Lorenzo Scaramuzzino, Giuseppe Lauletta*

Extragenital Lichen Sclerosus (LS) poses diagnostic and therapeutic challenges due to its rarity and varied
presentations. This report presents a case of LSaffecting the face, resistant to conventional therapies, successfully
treated with topical 5-Aminolevulinic Acid (ALA)-Photodynamic Therapy (PDT). A literature review highlights the
difficulty in diagnosing extragenital LS and discusses various treatment options, including corticosteroids, calcineurin
inhibitors, surgery, and emerging therapies such as ALA-PDT and Janus Kinase inhibitors (JAKi). ALA-PDT emerges
as a promising alternative for refractory cases, offering efficacy and safety, while JAKi presents a novel option for long-
term management.