Zeitschrift für medizinische Diagnosemethoden
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Antitumor Immunity Against Central Nervous System Tumors Is Induced By Bone Marrow–Generated Dendritic Cells Pulsed With Tumor Extracts Or Tumor RNA

Gloria Simmons

In this study, we looked at the efficacy of two types of vaccinations for the treatment of tumours in the CNS: dendritic cell (DC)-based antibodies that were beaten with either tumour concentrate or tumour RNA, and cytokine quality modified tumour antibodies. We show that vaccination with bone marrow–produced DCs, coupled with either B16 cell concentrate or B16 all out RNA, can induce explicit cytotoxic T lymphocytes against B16 tumour cells using the B16/F10 murine melanoma (B16) as a model for CNS tumour. The two types of DC antibodies had the ability to protect creatures from CNS malignancies. In mice with tumours implanted before the start of antibody treatment, DC-based vaccinations also resulted in a delay in endurance.