Zeitschrift für medizinische Diagnosemethoden
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Development of a Sensor Device with CMOS based Micro-Cantilevers for the Detection of Pulmonary Tuberculosis through Breath Analysis

Bhaveshwari Wagh*, Varsha Pandey, Deepti Jain

In this article we reported, a novel methodology for the detection of Mycobacterium tuberculosis (M. tuberculosis) infection in human that causes pulmonary tuberculosis; based on identifying specific breath biomarkers or VOC profile in the exhaled breath. On performing the gas chromatography/mass spectroscopy analysis for the biomarkers gave the different VOC patterns for the 2 group i.e., normal persons and the persons infected with the Mycobacterium tuberculosis. Based on these results a micro electro mechanical system technology is developed in the form of biological and chemical based micro cantilever sensors. This technique can enable efficient and non invasive detection for the early detection of pulmonary tuberculosis and can form the real time human surveillance system. Generally the breath biomarkers of active pulmonary TB in human are: Oxetane, 3-(1-methylene) dodecane, 4-methyl cyclohexane, 1, 3, 5- trimethyl decane, 3, 7-dimethyl heptanes, 1-nonane, 4, 6, 8-trimethyl heptanes.