Zeitschrift für Down-Syndrom und Chromosomenanomalien
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Model Review Selection for Aneuploid States

Jennifer Grove

Aneuploid segments of chromosomes, or abnormal numbers of chromosomes, are linked to a variety of genetic abnormalities and cancers. Many chromosomal defects are believed to be caused by a disruption of the genic equilibrium of protein complexes or pathways. The karyotype and gene expression profiles of 19 Drosophila modENCODE cell lines show how favourable gene copy numbers evolved when genic equilibrium was maintained. The copy number changes within genes encoding components of multiprotein complexes are consistent in these highly aneuploid cells, which may indicate good selection for genic balance.