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Abstrakt

Antioxidant and Anti-Inflammatory Activity of Nilavembu Kudineer Choornam: In Vitro Evaluation

Muthukumaran Pakkirisamy*, Nicholas Daniel, Jayaraj Mani

This present study was to investigate the invitro antioxidant and anti-inflammatory activity of aqueous extract of Nilavembu Kudineer Choornam (NKC). Phytochemical screening that used in the present study was a conventional method. The antioxidant activity was evaluated by various antioxidant assays, including DPPH, Nitric oxide (NO) Hydrogen peroxide (H₂O₂) scavenging and Reducing Power method. The antioxidant activities were compared to an antioxidant Ascorbic acid. The Nilavembu kudineer choornam (NKC) were extracted using water solvent into different concentration (50 mg/mLto 250 mg/mL). Diclofenac sodium was used as the standard. Anti-inflammatory assays were performed by the human red blood cell (HRBC) membrane stabilization method, antiproteinase activity and anti-lipoxygenase activity. Phytochemical screening showed the presence of Alkaloids, Flavonoids, Tannins, Steroids, Glycosides, Triterpenoids, Saponins and Phenol. Nilavembu kudineer choornam (NKC) showed a significant antioxidant and anti-inflammatory activity. The highest protection capability possessed by the extract of Nilavembu kudineer choornam (NKC) in human red blood cell (HRBC) membrane stabilization method, antiproteinase activity and anti-lipoxygenase activity was at a concentration of 250 mg/mL. The findings of the present study suggested that Nilavembu kudineer choornam (NKC) could be a potential natural source of antioxidants, anti-inflammatory activities by in vitro assays and could have greater importance as therapeutic agent in preventing or slowing oxidative stress related degenerative diseases.