Zeitschrift für klinische und experimentelle Dermatologieforschung
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Abstrakt

Evaluation of Effect of Topical Application of Ps-35 on Patients Affected with Chronic Plaque Psoriasis: A Clinical Study

Thomas J, Manoharan K, Dhanalakshmi A, Daniel SJ, Anbarasu Gowthaman A, Nappinnai M, Ranganathan S, Sundararajan M and Vasanth Kumar M

Background: Psoriasis is a chronic, immune-mediated, inflammatory systemic skin disorder that predominantly involves the skin, nails, and joints. It affects approximately 2% of the population and poses a lifelong burden on those, affected.
Objective: To evaluate the efficacy of topical application of Novel Botanical Formulation PS-35 on psoriasis affected areas of the body and to evaluate whether PS-35 can be recommended as safe and effective topical dosage form for treatment of plaque psoriasis.
Methods: Totally 185 patients were selected for the study on the basis of PASI score (<10%). Patients were given the topical application of PS-35 twice a day. The duration of therapy was at least 12 weeks and effect of withdrawal of therapy was observed for 15 weeks.
Results: The results showed the reduction in itchiness (90%), scaliness (91.5%), hard plaque (88%) and hyperpigmentation (78%). No relapse of psoriatic symptoms was observed in 56.6% patients.
Conclusion: The topical application of PS-35 is found to be an acceptable and effective method to treat symptoms of chronic plaque psoriasis.