Zeitschrift für Ozeanographie und Meeresforschung
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Marine Pharmaceuticals: A New Wave of Anti-angiogenic Drugs

Sweta Agrawal, Sachin Chaugule and Madhavi Indap*

The biodiversity of the marine environment and its associated chemical diversity constitute a practically unlimited resource of new active substances. Marine natural products (MNP) have exhibited a wide spectrum of pharmacological properties because of their bioactive secondary metabolites. At present, MNPs are progressively being used as anti-angiogenic drugs as summed up in several research reports. Although there are several anti-angiogenic marine natural products currently in different phases of clinical trials, challenges like large scale production of these drugs and further exploration of the marine sources still remain. This review summarizes the current knowledge on importance of marine bioactives as potential anti-angiogenic drugs. The report also highlights various MNPs altering angiogenic targets like endothelial cells, kinases, angiogenic growth factors and matrix metalloproteinases (MMPs).