Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
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Serum Asymmetric Dimethylarginine(ADMA) And Nitric Oxide(NO) : Their Pathophysiological Role In Patients With Preeclampsia And HELLP Syndrome

Tuna Akçal, Hanım Güler Şahin, Kazım Uçkan*

Objective: This study aims to investigate the role of serum asymmetric dimethylarginine and nitric oxide levels in the pathogenesis and severity of hemolysis, elevated liver enzymes, and low platelets syndrome, Eclampsia, and Pre-eclampsia.

Methods and methods: A total of 90 patients including hemolysis, elevated liver enzymes, and low platelets syndrome (n=30), Eclampsia (n=30), and Pre-eclampsia (n=30) were included in the study. Pregnancy was calculated according to the last menstrual period and ultrasonographic fetal biometric measurements, and only patients with a 32-week and above pregnancy were included. Similarly, 30 healthy pregnant women in the same age and gestational week who were admitted for pregnancy control were included in the study. Serum asymmetric dimethylarginine, Arginine and nitric oxide levels were measured for all four groups.

Results: There was no statistically significant difference in the age, gravida, parity, gestational week, hemoglobin, fibrinogen, international normalized ratio, and Arginine among the hemolysis, elevated liver enzymes, and low platelets, Eclampsia, Pre-eclampsia and control groups (p>0.05). In the hemolysis, elevated liver enzymes, and low platelets group, Eclampsia pregnant group, and late-onset Pre-eclampsia group, systolic blood pressure and diastolic blood pressure, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase and asymmetric dimethylarginine levels significantly increased (p<0.001). On the other hand, platelet and nitric oxide levels decreased, compared to the control group (p<0.001).

Conclusions: Our study results suggest that asymmetric dimethylarginine and nitric oxide levels may be useful for predicting complications such as Eclampsia, Pre-eclampsia, and hemolysis, elevated liver enzymes, and low platelets syndrome and can be helpful in tailoring necessary treatment for each individual patient.