Zeitschrift für klinische und experimentelle Ophthalmologie
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Agreement in Quantitative Anterior Chamber Angle Metrics between RTVue and Cirrus Spectral Domain Optical Coherence Tomography

Anna Ι Dastiridou, Kenneth M Marion, Moritz Niemeyer, Brian A Francis, Srinivas R Sadda and Vikas Chopra

Purpose: To investigate the agreement between two spectral domain optical coherence tomography (SD-OCT) instruments in Schwalbe’s line (SL) based anterior chamber angle parameters and to evaluate their repeatability and reproducibility.
Methods: The inferior irido-corneal angle of 114 eyes from 59 participants (29 glaucoma and 30 normal) were scanned twice with the Optovue SD-OCT and Cirrus SD-OCT under controlled low luminance conditions. SL angle opening distance (SL-AOD) and SL trabecular-iris-space area (SL-TISA) were graded by masked certified graders at the Doheny Image Reading Center.
Results: The mean SL-AOD/SL-TISA was 623±271μm/ 0.221 ± 0.106 mm2 for the Cirrus and 611 ± 267 μm/ 0.215 ± 0.112 mm2 for the RTVue. Excellent repeatability (intraclass correlation coefficient ICC>0.934), excellent intragrader reproducibility (ICC>0.957) and very good intergrader reproducibility (ICC>0.877) were observed with both instruments in SL-AOD and SL-TISA. The agreement between Cirrus and RTVue was excellent (ICC 0.943 for SL-AOD and 0.900 for SL-TISA).
Conclusion: Both instruments provide consistent and reproducible measurement of SL-AOD and SL-TISA. The excellent agreement between them allows for direct comparisons of angle measurements acquired with different SDOCTs and can lead in the introduction of criteria that could be valid across different platforms